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《Toxicology Research》第五卷第1期论文目录
【 日期:2016-1-11    发布:中国毒理学会 】




Toxicology Research,01 January 2016, Issue 1, Page 1 to 356
链接:http://pubs.rsc.org/en/journals/journalissues/tx#!issueid=tx005001

CONTENTS
Review Article
(综述)

1. Key mechanisms involved in ionizing radiation-induced systemic effects. A current review
电离辐射致系统效应的主要机制
Ifigeneia V. Mavragani, Danae A. Laskaratou, Benjamin Frey, Serge M. Candéias, Udo S. Gaipl, Katalin Lumniczky and Alexandros G. Georgakilas
Toxicol. Res., 2016, 5, 12-33 DOI: 10.1039/C5TX00222B

Papers (论著)
1. Mechanistic understanding of molecular initiating events (MIEs) using NMR spectroscopy
利用核磁共振阐释分子起始事件(MIEs)的机制
Paul N. Sanderson, Wendy Simpson, Richard Cubberley, Maja Aleksic, Stephen Gutsell and Paul J. Russell
Toxicol. Res., 2016, 5, 34-44 DOI: 10.1039/C5TX00246J

2. Cytotoxic effects of aspartame on human cervical carcinoma cells
阿斯巴甜对人类宫颈癌细胞的细胞毒性
Muthuraman Pandurangan, Gansukh Enkhtaivan and Doo Hwan Kim
Toxicol. Res., 2016, 5, 45-52 DOI: 10.1039/C5TX00269A

3. Red wine polyphenol extract efficiently protects intestinal epithelial cells from inflammation via opposite modulation of JAK/STAT and Nrf2 pathways
红酒多酚通过负向调节JAK/STAT 和 Nrf2通路有效保护肠上皮细胞免受炎症损伤
Carla Nunes, Natércia Teixeira, Diana Serra, Víctor Freitas, Leonor Almeida and João Laranjinha
Toxicol. Res., 2016, 5, 53-65 DOI: 10.1039/C5TX00214A

4. HIF-2α, acting via miR-191, is involved in angiogenesis and metastasis of arsenite-transformed HBE cells
HIF-2α通过miR-191介导亚砷酸盐诱导HBE细胞转化的血管生成和转移
Wenchao Xu, Fei Luo, Baofei Sun, Hua Ye, Jun Li, Le Shi, Yi Liu, Xiaolin Lu, Bairu Wang, Qingling Wang, Qizhan Liu and Aihua Zhang
Toxicol. Res., 2016, 5, 66-78 DOI: 10.1039/C5TX00225G

5. Intravenous injection of L-BMAA induces a rat model with comprehensive characteristics of amyotrophic lateral sclerosis/Parkinson–dementia complex
静脉注射L-BMAA诱发大鼠肌萎缩侧索硬化/帕金森综合征-痴呆综合征
Ke-Wei Tian, Hong Jiang, Bei-Bei Wang, Fan Zhang and Shu Han
Toxicol. Res., 2016, 5, 79-96 DOI: 10.1039/C5TX00272A

6. Evaluation of zinc-doped magnetite nanoparticle toxicity in the liver and kidney of mice after sub-chronic intragastric administration
掺锌磁铁纳米颗粒亚慢性经口试验评估小鼠的肝肾毒性
Shanshan Zhu, Xiaolong Xu, Rui Rong, Bing Li and Xue Wang
Toxicol. Res., 2016, 5, 97-106 DOI: 10.1039/C5TX00292C

7. Cumulative metabolic effects of low-dose benzo(a)pyrene exposure on human cells
低浓度苯并(a)芘暴露在人体细胞中的累积代谢效应
Qian Ba, Chao Huang, Yijing Fu, Junyang Li, Jingquan Li, Ruiai Chu, Xudong Jia and Hui Wang
Toxicol. Res., 2016, 5, 107-115 DOI: 10.1039/C5TX00378D

8. Sodium tanshinone IIA sulfonate suppresses pulmonary fibroblast proliferation and activation induced by silica: role of the Nrf2/Trx pathway
丹参酮ⅡA磺酸钠抑制二氧化硅诱导的肺成纤维细胞的增殖活化:Nrf2/Trx通路的作用
Zhonghui Zhu, Yan Wang, Di Liang, Gengxia Yang, Li Chen, Piye Niu and Lin Tian
Toxicol. Res., 2016, 5, 116-125 DOI: 10.1039/C5TX00291E

9. Evaluation of CdTe/CdS/ZnS core/shell/shell quantum dot toxicity on three-dimensional spheroid cultures
CdTe/CdS/ZnS核-壳量子点对三维球形培养细胞的毒性评价
Mehriban Ulusoy, Antonina Lavrentieva, Johanna-Gabriela Walter, Franziska Sambale, Mark Green, Frank Stahl and Thomas Scheper
Toxicol. Res., 2016, 5, 126-135 DOI: 10.1039/C5TX00236B

10. Effects of mid-respiratory chain inhibition on mitochondrial function in vitro and in vivo
中呼吸链抑制对线粒体功能的影响的体内、体外试验
Ashley J. Broom, Jeffrey Ambroso, Gino Brunori, Angie K. Burns, James R. Armitage, Ian Francis, Mitul Gandhi, Richard A. Peterson, Timothy W. Gant, Alan R. Boobis and Jonathan J. Lyon
Toxicol. Res., 2016, 5, 136-150 DOI: 10.1039/C5TX00197H

11. Identification of Id1 as a downstream effector for arsenic-promoted angiogenesis via PI3K/Akt, NF-κB and NOS signaling
Id1是砷经PI3K/Akt, NF-κB a和NOS信号通路促血管生成的下游效应器
Chun-Hao Tsai, Ming-Hui Yang, Amos C. Hung, Shou-Cheng Wu, Wen-Chin Chiu, Ming-Feng Hou, Yu-Chang Tyan, Yun-Ming Wang and Shyng-Shiou F. Yuan
Toxicol. Res., 2016, 5, 151-159 DOI: 10.1039/C5TX00280J

12. miR-122 plays an important role in ochratoxin A-induced hepatocyte apoptosis in vitro and in vivo
miR-122在赭曲霉素A诱导体内、外肝细胞凋亡中发挥重要作用
Liye Zhu, Tao Yu, Xiaozhe Qi, Bo Yang, Lei Shi, Haoshu Luo, Xiaoyun He, Kunlun Huang and Wentao Xu
Toxicol. Res., 2016, 5, 160-167 DOI: 10.1039/C5TX00104H

13. Evaluation of potential acute cardiotoxicity of biodegradable nanocapsules in rats by intravenous administration
静脉注射可生物降解纳米胶囊对大鼠潜在的急性心脏毒性评价
Rafael Fracasso, Marília Baierle, Gabriela Goëthel, Anelise Barth, Fernando Freitas, Sabrina Nascimento, Louise Altknecht, Virgilio Olsen, Karina Paese, Vinicius Duval da Silva, Iran Castro, Michael Andrades, Nadine Clausell, Adriana Pohlmann, Silvia Guterres and Solange Cristina Garcia
Toxicol. Res., 2016, 5, 168-179 DOI: 10.1039/C5TX00207A

14. The effect of “Jelly” CdTe QD uptake on RAW264.7 monocytes: immune responses and cell fate study
摄入“胶状”碲化镉量子点(“Jelly” CdTe QD)对RAW264.7单核细胞的影响:免疫应答和细胞结局研究
O. Gladkovskaya, A. Loudon, M. Nosov, Y. K. Gun'ko, G. M. O'Connor and Y. Rochev
Toxicol. Res., 2016, 5, 180-187 DOI: 10.1039/C5TX00153F

15. Kavain inhibition of LPS-induced TNF-α via ERK/LITAF
醉椒素经由ERK/LITAF通路抑制LPS诱导的TNF-α生成
Xiaoren Tang and Salomon Amar
Toxicol. Res., 2016, 5, 188-196 DOI: 10.1039/C5TX00164A

16. Effect of base sequence context on the conformational heterogeneity of aristolactam-I adducted DNA: structural and energetic insights into sequence-dependent repair and mutagenicity
碱基序列对马兜铃内酰胺-I DNA加合物构象的影响:序列依赖的修复和致突变性的结构和量能分析
Preetleen Kathuria, Purshotam Sharma and Stacey D. Wetmore
Toxicol. Res., 2016, 5, 197-209 DOI: 10.1039/C5TX00302D

17. Mouse hepatic neoplasm formation induced by trace level and low frequency exposure to diethylnitrosamine through β-catenin signaling pathway
痕量低频二乙基亚硝胺暴露通过β-连环素信号通路诱导小鼠肝脏肿瘤发生
Yu-Sang Li, Chang-Long Leng, Man-Tang Chen, Wei Kevin Zhang, Xiao-Jun Li, He-Bin Tang, Hong-Cai Shang and Li-Hua Zhu
Toxicol. Res., 2016, 5, 210-223 DOI: 10.1039/C5TX00317B

18. Grape seed proanthocyanidin extract protects against perfluorooctanoic acid-induced hepatotoxicity by attenuating inflammatory response, oxidative stress and apoptosis in mice
葡萄籽原花青素提取物(GSPE)通过降低炎症应答、氧化应激和凋亡拮抗全氟辛酸诱导的肝毒性
Wenwen Liu, Changshui Xu, Xi Sun, Haibin Kuang, Xiaodong Kuang, Weiying Zou, Bei Yang, Lei Wu, Fangming Liu, Ting Zou and Dalei Zhang
Toxicol. Res., 2016, 5, 224-234 DOI: 10.1039/C5TX00260E

19. In vitro toxicity evaluation of silica-coated iron oxide nanoparticles in human SHSY5Y neuronal cells
二氧化硅包裹氧化铁纳米颗粒对人SHSY5Y神经元细胞的体外毒性评价
Gözde Kiliç, Carla Costa, Natalia Fernández-Bertólez, Eduardo Pásaro, João Paulo Teixeira, Blanca Laffon and Vanessa Valdiglesias
Toxicol. Res., 2016, 5, 235-247 DOI: 10.1039/C5TX00206K

20. Toxicity mechanism in fetal lung fibroblast cells for multi-walled carbon nanotubes defined by chemical impurities and dispersibility
不同化学纯度和分散度的多壁层碳纳米管对胚肺成纤维细胞的毒性作用机制
Aparna Shinde and Candace S. J. Tsai
Toxicol. Res., 2016, 5, 248-258 DOI: 10.1039/C5TX00211G

21. Screening and validation for plasma biomarkers of nephrotoxicity based on metabolomics in male rats
应用代谢组学筛查和验证雄性大鼠的肾毒性血浆生物标志物
Yubo Li, Haoyue Deng, Liang Ju, Xiuxiu Zhang, Zhenzhu Zhang, Zhen Yang, Lei Wang, Zhiguo Hou and Yanjun Zhang
Toxicol. Res., 2016, 5, 259-267 DOI: 10.1039/C5TX00171D

22. Acute exposure of ozone induced pulmonary injury and the protective role of vitamin E through the Nrf2 pathway in Balb/c mice
臭氧急性染毒诱导Balb/c小鼠肺部损伤及Nrf2通路介导维生素E的保护作用
Yuqing Zhu, Jinquan Li, Zhuo Wu, Yu Lu, Huihui You, Rui Li, Baizhan Li, Xu Yang and Liju Duan
Toxicol. Res., 2016, 5, 268-277 DOI: 10.1039/C5TX00259A

23. Pancreatic progenitor-derived hepatocytes are viable and functional in a 3D high density bioreactor culture system
胰腺前体衍生肝细胞可在三维高密度生物反应器培养体系中存活并保持功能
M. Richter, E. A. Fairhall, S. A. Hoffmann, S. Tröbs, F. Knöspel, P. M. E. Probert, F. Oakley, A. Stroux, M. C. Wright and K. Zeilinger
Toxicol. Res., 2016, 5, 278-290 DOI: 10.1039/C5TX00187K

24. A quantitative proteomic approach for unveiling novel mechanisms associated with MeHg-induced toxicity: effects on the methylation cycle
定量蛋白组学法揭示MeHg介导的毒性效应新机制:对甲基化循环的影响
Pablo Cabezas-Sanchez, Estefania Garcia-Calvo, Carmen Camara and Jose L. Luque-Garcia
Toxicol. Res., 2016, 5, 291-302 DOI: 10.1039/C5TX00354G

25. Evaluation of the intracellular uptake and cytotoxicity effect of TiO2 nanostructures for various human oral and lung cells under dark conditions
TiO2纳米材料在暗环境下对人口腔和肺细胞内吞作用和细胞毒性效应的评价
Chieh-Wei Chen, Jing-Hong Huang, Tsung-Ching Lai, Yi-Hua Jan, Michael Hsiao, Chung-Hsuan Chen, Yeu-Kuang Hwu and Ru-Shi Liu
Toxicol. Res., 2016, 5, 303-311 DOI: 10.1039/C5TX00312A

26. Using 3D MCF-7 mammary spheroids to assess the genotoxicity of mixtures of the food-derived carcinogens benzo[a]pyrene and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
利用三维MCF-7 乳腺癌细胞球形培养模型评价食源性致癌物苯并[a]芘和2-氨基-1-甲基-6-苯基-咪唑[4,5-b]吡啶混合物的遗传毒性
Rhiannon M. David and Nigel J. Gooderham
Toxicol. Res., 2016, 5, 312-317 DOI: 10.1039/C5TX00343A

27. Cytotoxic and sublethal effects of silver nanoparticles on tendon-derived stem cells – implications for tendon engineering
银纳米粒子对肌腱干细胞的细胞毒性作用和亚致死效应: 对肌腱组织工程的启示
Tik Shing Cheung, Pui Man Lau, Haifei Lu, Ho Pui Ho, Pauline Po Yee Lui and Siu Kai Kong
Toxicol. Res., 2016, 5, 318-330 DOI: 10.1039/C5TX00349K

28. Effects of probucol on cell proliferation in human ovarian cancer cells
普罗布考对人类卵巢癌细胞增生的影响
Lea-Yea Chuang, Jinn-Yuh Guh, Yi-Ling Ye, Ying-Ho Lee and Jau-Shyang Huang
Toxicol. Res., 2016, 5, 331-339 DOI: 10.1039/C5TX00088B

29. Modeling the toxicity of chemical pesticides in multiple test species using local and global QSTR approaches
利用区域和整体定量构效关系QSTR对农药的多种实验生物的毒性进行建模
Nikita Basant, Shikha Gupta and Kunwar P. Singh
Toxicol. Res., 2016, 5, 340-353 DOI: 10.1039/C5TX00321K

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